Background: Hyperpigmentation disorders such as post-inflammatory hyperpigmentation are major concerns not\nonly in light-skinned people but also in Asian populations with darker skin. The anti-tyrosinase and immunomodulatory\neffects of sericin have been known for decades. However, the therapeutic effects of sericin on hyperpigmentation\ndisorders have not been well documented.\nMethods: In this study, we used an in vitro model to study the anti-tyrosinase, tolerogenic, and anti-melanogenic\neffects of sericin on Staphylococcus aureus peptidoglycan (PEG)-stimulated melanocytes, dendritic cells (DCs), and\nartificial skin (MelanoDerm). Enzyme-linked immunosorbent assay, conventional and immunolabeled electron\nmicroscopy, and histopathological studies were performed.
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